There have been numerous vaccines throughout history that have played a crucial role in saving lives and protecting humanity from deadly diseases ,  here are five examples of vaccines that have had a significant impact:

Smallpox vaccine: Smallpox was a highly contagious and deadly disease responsible for millions of deaths throughout history. The smallpox vaccine, developed by Edward Jenner in the late 18th century and later improved by others, was the first vaccine ever created.

Polio vaccine: Polio is a viral disease that can cause paralysis and even death. The development of polio vaccines by Jonas Salk (inactivated polio vaccine) and Albert Sabin (oral polio vaccine) in the mid-20th century was a major breakthrough. 

Measles vaccine: Measles is a highly contagious viral disease that can lead to severe complications, including pneumonia and encephalitis. The measles vaccine, introduced in the 1960s, has significantly reduced the global incidence of measles and prevented millions of deaths, particularly in children.

Hepatitis B vaccine: Hepatitis B is a viral infection that affects the liver and can cause chronic liver disease and liver cancer. The development of a safe and effective hepatitis B vaccine in the 1980s has been instrumental in preventing new infections and reducing the burden of this disease worldwide.

Human papillomavirus (HPV) vaccine: HPV is a sexually transmitted infection that can cause various types of cancer, including cervical cancer, as well as genital warts. The introduction of HPV vaccines in the early 2000s has had a significant impact on reducing HPV-related diseases